FOR IMMEDIATE RELEASE

Real-time left ventricular (LV) pressure-volume loops provide a load independent framework for understanding cardiac mechanics in a manner which electrophysiology and dp/dt analysis cannot. Such loops can be generated by real time measurement of pressure and volume within the left ventricle. Many physiologically relevant hemodynamic parameters such as stroke volume, cardiac output, ejection fraction, myocardial contractility, etc. can be determined from these loops.

Dr. Richard Klabunde will explain the pressure and volume changes during the cardiac cycle and the significance of major pressure volume relationships including end systolic (ESPVR), preload recruitable stroke work (PRSW), and end diastolic (EDPVR).

Other topics to be covered include:

·         Effects of preload, afterload and inotropy on PV loops

·         Generation of PV loops and ESPVR and EDPVR in-vivo

·         Examples of abnormal PV loops:

o        Heart Failure (diastolic and systolic dysfunction)

o        Left Ventricular Hypertrophy and Ischemia

·         Summary of importance of PV loops in assessing ventricular function

A good understanding of PV Loops is essential to quality data collection and interpretation of Cardiac Function Assessment. To help you better understand the scientific concepts Scisense invites you to take part in our free PV Loop Web Seminar on March 30, 2011. Visit the Scisense WebEx portal to register and for details: https://scisense.webex.com

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About Dr. Richard Klabunde

Dr. Richard Klabunde, author of "Cardiovascular Physiology Concepts" is an Associate Professor of Physiology at the Ohio University. Dr. Klabunde has served as the Director of the Clinical Presentation Continuum Curriculum for the medical school overseeing all the Medical Knowledge and Clinical Skills courses taught during the first two years. More information on Dr. Klabunde can be found at: www.cvphysiology.com

About Scisense

Scisense designs and manufactures high fidelity micro-sensors for use in cardiac research. Blood pressure and pressure-volume sensors from Scisense are used worldwide by scientists in search of a cure for heart disease and by pharmaceutical companies in safety and drug testing.

More information about Scisense can be found at www.scisense.com.

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