Online Educational Webinar to Explain Systolic and Diastolic Function in Rodent Models of Metabolic Syndrome

20-Jul-2011 | News-Press Release

For Immediate Release

July, 18, 2011 - Scisense Systems Inc. hosts Dr. DeMarco from the University of Missouri. Dr. DeMarco will give an overview and summary of the PV loop data from transgenic Ren2 and Zucker obese rat models. Furthermore, he will review the results describing the cardiac dysfunction and address some of the technicalities and challenges of data acquisition. To register or to learn more please go to:


Both the Ren2 and ZO rats are insulin resistant; however the mechanisms driving heart failure are distinct. The Ren2 model is a model of tissue renin-angiotensin system (RAS) activation due to expression the mouse renin gene in multiple tissues including the heart. Tissue RAS activation in the Ren2 rat is responsible for impaired insulin metabolic signaling and oxidative stress which contributes to hypertension and end organ damage. Ren2 rats are lean and active yet exhibit dyslipidemia. On the other hand, cardiovascular disease in the ZO rat that has a leptin receptor mutation is driven by over nutrition and obesity.


Dr. DeMarco will illustrate some ideas presented in previous webinars to tie the series of talks together.


Topics to be covered include:

·         Effects of arrhythmias on PV traces

·         Proper phase and magnitude traces indicating good catheter placement

·         Comparison of PV, MRI and echo data


The focus of the webinar will be on the various haemodynamic parameters determined using PV loops and how it would have been impossible to arrive at the conclusions drawn without a PV loop measurement system. Scisense invites you to participate in our free webinar entitled Assessment of systolic and diastolic function in rodent models of metabolic syndrome. Visit the Scisense WebEx portal to register and for details:



About Dr. DeMarco

Dr. DeMarco received his PhD in Zoology at the University of Florida in 1991. In 1995 he joined the faculty in Pediatrics (Neonatology) at UF and in 2002 moved on to the University of Missouri where he now holds a position as an Associate Research Professor in the division of Endocrinology. Dr. DeMarco is broadly engaged in research on cardiovascular diseases and his specific focus in the last few years addresses the underlying mechanisms leading to development of cardiovascular diseases in the context of cardiorenal syndrome (hypertension, obesity, insulin resistance, chronic kidney disease, and diabetes).


About Scisense

Scisense Systems Inc. specializes in micro-sensing technologies for use in preclinical research. Products include high-fidelity pressure sensors used to measure blood pressure, pressure-volume catheters, and catheters for electrophysiology applications. The company head office and manufacturing facilities are located in London, Ontario, Canada and operates offices through its alliance with Transonics Systems in the U.S., Europe, Taiwan and Japan. Since its incorporation in 2002, Scisense has focused on contributing to the advancement of research into cardiac disease and has established itself as a technology leader. The company employs an expert staff of engineers and scientists, and proudly supports an extensive network of customers at universities, pharmaceutical companies and contract research organizations throughout the world. For more information about Scisense, Inc., please visit our website at

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